Homo sapiens Protein: GRB10 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-293559.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | GRB10 | ||||||||||||||||||||||
Protein Name | growth factor receptor-bound protein 10 | ||||||||||||||||||||||
Synonyms | Grb-10; GRB-IR; IRBP; MEG1; RSS; | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000385046 | ||||||||||||||||||||||
InnateDB Gene | IDBG-16688 (GRB10) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin- stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin- stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. {ECO:0000269PubMed:12493740, ECO:0000269PubMed:15060076, ECO:0000269PubMed:16434550, ECO:0000269PubMed:17376403}. | ||||||||||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000250}. Note=When complexed with NEDD4 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment (By similarity). {ECO:0000250}. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Widely expressed in fetal and adult tissues, including fetal and postnatal liver, lung, kidney, skeletal muscle, heart, spleen, skin and brain. {ECO:0000269PubMed:11527390}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR000159
Ras-association IPR000980 SH2 domain IPR001849 Pleckstrin homology domain IPR015042 BPS (Between PH and SH2) domain IPR029071 Ubiquitin-related domain |
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PFAM |
PF00788
PF00017 PF14633 PF00169 PF08947 |
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PRINTS |
PR00401
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PIRSF | |||||||||||||||||||||||
SMART |
SM00314
SM00252 SM00233 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q13322 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q13322 | ||||||||||||||||||||||
TrEMBL | Q75MT1 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 2887 | ||||||||||||||||||||||
UniGene | Hs.737720 | ||||||||||||||||||||||
RefSeq | |||||||||||||||||||||||
HUGO | HGNC:4564 | ||||||||||||||||||||||
OMIM | 601523 | ||||||||||||||||||||||
CCDS | CCDS43583 | ||||||||||||||||||||||
HPRD | 03312 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AB000731 AC005153 AC080092 AF000017 AF001534 AF073363 AF073364 AF073365 AF073366 AF073367 AF073368 AF073369 AF073370 AF073371 AF073372 AF073373 AF073374 AF073375 AF073376 AF073377 AF073378 AJ271366 AK289511 BC024285 CH236955 CH471128 D86962 U34355 U66065 U69276 | ||||||||||||||||||||||
GenPept | AAA88819 AAB08431 AAB81134 AAC19748 AAC50671 AAC83654 AAC83655 AAH24285 AAS00377 AAS07426 BAA13198 BAF76353 BAF82200 CAB96542 EAL23897 EAW60964 EAW60965 EAW60967 | ||||||||||||||||||||||