Version 5.4
Homo sapiens Protein: SNRNP70
Summary
InnateDB Protein IDBP-293972.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SNRNP70
Protein Name small nuclear ribonucleoprotein 70kDa (U1)
Synonyms RNPU1Z; RPU1; Snp1; SNRP70; U1-70K; U170K; U1AP; U1RNP;
Species Homo sapiens
Ensembl Protein ENSP00000385077
InnateDB Gene IDBG-62088 (SNRNP70)
Protein Structure
UniProt Annotation
Function Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA.
Subcellular Localization Nucleus. Nucleus speckle {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Note=Colocalizes with SCNM1 and LUC7L2 in nuclear speckles. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 133 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 133 [view]
Protein-Protein 133 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0043484 regulation of RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005685 U1 snRNP
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
IPR022023 U1 small nuclear ribonucleoprotein of 70kDa N-terminal
PFAM PF00076
PF12220
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P08621
PhosphoSite PhosphoSite-P08621
TrEMBL M0QYR1
UniProt Splice Variant
Entrez Gene 6625
UniGene Hs.467097
RefSeq
HUGO HGNC:11150
OMIM 180740
CCDS
HPRD 01617
IMGT
EMBL AC008687 AK096783 AL117507 BC001315 CH471177 M22636 M57929 M57930 M57932 M57934 M57935 M57937 M57939 X04654 X06811 X06812 X06814 X06815 X06816 X06817 X07401 X07402 X07403 X84841
GenPept AAA03001 AAA36571 AAA36572 AAA36573 AAH01315 BAG53365 CAA28352 CAA29960 CAA29961 CAA29963 CAA29964 CAA29965 CAA29966 CAA30303 CAA30304 CAA30305 CAA59278 CAB55969 EAW52449

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca