Version 5.4
Homo sapiens Protein: HNRPLL
Summary
InnateDB Protein IDBP-293988.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HNRPLL
Protein Name heterogeneous nuclear ribonucleoprotein L-like
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000387088
InnateDB Gene IDBG-46416 (HNRPLL)
Protein Structure
UniProt Annotation
Function RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC. {ECO:0000269PubMed:18669861}.
Subcellular Localization
Disease Associations
Tissue Specificity Widely expressed. Detected in bone marrow stroma cells, skeletal muscle, heart, placenta, pancreas, kidney and lung. {ECO:0000269PubMed:15256261}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006397 mRNA processing
GO:0033120 positive regulation of RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
IPR006536 HnRNP-L/PTB/hephaestus splicing factor
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WVV9
PhosphoSite PhosphoSite-Q8WVV9
TrEMBL
UniProt Splice Variant
Entrez Gene 92906
UniGene Hs.445497
RefSeq NP_001136122
HUGO HGNC:25127
OMIM 611208
CCDS CCDS46261
HPRD 13667
IMGT
EMBL AC011247 AF461712 AF461713 AF461714 AF461715 AF461716 AF461717 AF461718 AF461719 AF461720 AF461721 AF461722 AK291462 AL512692 AY236962 AY236963 BC008217 BC017480
GenPept AAH08217 AAH17480 AAN76189 AAN76190 AAQ20083 AAQ20084 AAY24302 BAF84151 CAH56358

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca