InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RASGRP3

Summary

InnateDB Protein

IDBP-294134.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RASGRP3

Protein Name

RAS guanyl releasing protein 3 (calcium and DAG-regulated)

Synonyms

GRP3;

Species

Homo sapiens

Ensembl Protein

ENSP00000384192

InnateDB Gene

IDBG-43993 (RASGRP3)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide exchange factor (GEF) for Ras and Rap1. {ECO:0000269PubMed:10934204}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005088	Ras guanyl-nucleotide exchange factor activity
GO:0005509	calcium ion binding
GO:0017016	Ras GTPase binding
GO:0019900	kinase binding
GO:0019992	diacylglycerol binding
GO:0046582	Rap GTPase activator activity

Biological Process

GO:0000165	MAPK cascade
GO:0007264	small GTPase mediated signal transduction
GO:0007265	Ras protein signal transduction
GO:0032854	positive regulation of Rap GTPase activity
GO:0035556	intracellular signal transduction
GO:0043087	regulation of GTPase activity
GO:0043547	positive regulation of GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0032045	guanyl-nucleotide exchange factor complex
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
IPR002048 EF-hand domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR020454 Diacylglycerol/phorbol-ester binding
IPR023578 Ras guanine nucleotide exchange factor domain

PFAM

PF00618
PF00617
PF00036
PF13202
PF13405
PF00130

PRINTS

PR00008

PIRSF

SMART

SM00229
SM00147
SM00054
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt