InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TF

Summary

InnateDB Protein

IDBP-294481.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Protein Name

transferrin

Synonyms

PRO1557; PRO2086; TFQTL1;

Species

Homo sapiens

Ensembl Protein

ENSP00000385834

InnateDB Gene

IDBG-57280 (TF)

Protein Structure

UniProt Annotation

Function

Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.

Subcellular Localization

Secreted.

Disease Associations

Atransferrinemia (ATRAF) [MIM:209300]: A rare autosomal recessive disorder characterized by abnormal synthesis of transferrin leading to iron overload and microcytic hypochromic anemia. {ECO:0000269PubMed:11110675, ECO:0000269PubMed:15466165}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed by the liver and secreted in plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	35 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008199	ferric iron binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0001895	retina homeostasis
GO:0002576	platelet degranulation
GO:0006826	iron ion transport
GO:0006879	cellular iron ion homeostasis
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0033572	transferrin transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005769	early endosome
GO:0005770	late endosome
GO:0005905	coated pit
GO:0009925	basal plasma membrane
GO:0009986	cell surface
GO:0010008	endosome membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0016324	apical plasma membrane
GO:0030139	endocytic vesicle
GO:0034774	secretory granule lumen
GO:0045178	basal part of cell
GO:0048471	perinuclear region of cytoplasm
GO:0055037	recycling endosome
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle