InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DBI

Summary

InnateDB Protein

IDBP-294549.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DBI

Protein Name

diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)

Synonyms

ACBD1; ACBP; CCK-RP; EP;

Species

Homo sapiens

Ensembl Protein

ENSP00000386486

InnateDB Gene

IDBG-67980 (DBI)

Protein Structure

UniProt Annotation

Function

Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.

Subcellular Localization

Endoplasmic reticulum. Golgi apparatus. Note=Golgi localization is dependent on ligand binding.

Disease Associations

Tissue Specificity

Isoform 1 is ubiquitous, with a moderate expression level. Isoform 2 is ubiquitous with high level in liver and adipose tissue. Isoform 3 is ubiquitous with strong expression in adipose tissue and heart. {ECO:0000269PubMed:16055366, ECO:0000269PubMed:21698759}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	18 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000062	fatty-acyl-CoA binding
GO:0008289	lipid binding
GO:0030156	benzodiazepine receptor binding
GO:0036042	long-chain fatty acyl-CoA binding
GO:0046983	protein dimerization activity