InnateDB Protein
|
IDBP-294643.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
MAPRE3
|
Protein Name
|
microtubule-associated protein, RP/EB family, member 3
|
Synonyms
|
EB3; EBF3; EBF3-S; RP3;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000385715
|
InnateDB Gene
|
IDBG-36353 (MAPRE3)
|
Protein Structure
|
|
Function |
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000269PubMed:10644998, ECO:0000269PubMed:19255245}. Note=Associated with the microtubule network. Detected at the plus end of microtubules.
|
Disease Associations |
|
Tissue Specificity |
Predominantly expressed in brain and muscle. {ECO:0000269PubMed:10644998}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
19
[view]
|
Protein-Protein |
19
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
GO:0007067
|
mitotic nuclear division
|
GO:0045737
|
positive regulation of cyclin-dependent protein serine/threonine kinase activity
|
GO:0045893
|
positive regulation of transcription, DNA-templated
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001715
Calponin homology domain
IPR004953
EB1, C-terminal
|
PFAM |
PF00307
PF03271
|
PRINTS |
|
PIRSF |
|
SMART |
SM00033
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9UPY8
|
PhosphoSite |
PhosphoSite-Q9UPY8
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
22924
|
UniGene |
Hs.515860
|
RefSeq |
|
HUGO |
HGNC:6892
|
OMIM |
605788
|
CCDS |
|
HPRD |
16156
|
IMGT |
|
EMBL |
AB025186
AC013472
AF288787
BC011557
CH471053
CR536523
CR541845
Y11174
|
GenPept |
AAH11557
AAK07556
AAK07557
AAY14653
BAA82958
CAA72060
CAG38760
CAG46643
EAX00660
EAX00662
EAX00663
EAX00666
|
|
|