InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AP1B1

Summary

InnateDB Protein

IDBP-294693.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AP1B1

Protein Name

adaptor-related protein complex 1, beta 1 subunit

Synonyms

ADTB1; AP105A; BAM22; CLAPB2;

Species

Homo sapiens

Ensembl Protein

ENSP00000386071

InnateDB Gene

IDBG-3567 (AP1B1)

Protein Structure

UniProt Annotation

Function

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

Subcellular Localization

Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.

Disease Associations

Tissue Specificity

Widely expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	62 [view]
Protein-Protein	61 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005488	binding
GO:0005515	protein binding
GO:0008565	protein transporter activity
GO:0019901	protein kinase binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006892	post-Golgi vesicle-mediated transport
GO:0015031	protein transport
GO:0016032	viral process
GO:0016192	vesicle-mediated transport
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0050690	regulation of defense response to virus by virus
GO:0061024	membrane organization

Cellular Component

GO:0000139	Golgi membrane
GO:0005765	lysosomal membrane
GO:0005829	cytosol
GO:0030117	membrane coat
GO:0030131	clathrin adaptor complex
GO:0030659	cytoplasmic vesicle membrane
GO:0030665	clathrin-coated vesicle membrane
GO:0032588	trans-Golgi network membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000225 Armadillo
IPR000357 HEAT
IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal
IPR008152 Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
IPR009028 Coatomer/calthrin adaptor appendage, C-terminal subdomain
IPR013041 Coatomer/clathrin adaptor appendage, Ig-like subdomain
IPR015151 Beta-adaptin appendage, C-terminal subdomain
IPR016024 Armadillo-type fold
IPR016342 AP-1, 2,4 complex subunit beta

PFAM

PF00514
PF02985
PF01602
PF02883
PF09066

PRINTS

PIRSF

PIRSF002291

SMART

SM00185
SM00809
SM01020

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt