InnateDB Protein
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IDBP-294767.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ZNRF3
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Protein Name
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zinc and ring finger 3
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000384553
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InnateDB Gene
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IDBG-3438 (ZNRF3)
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Protein Structure
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Function |
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non- canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. {ECO:0000269PubMed:22575959}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:22575959}; Single-pass type I membrane protein {ECO:0000269PubMed:22575959}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
13
[view]
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Protein-Protein |
12
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006511
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ubiquitin-dependent protein catabolic process
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GO:0016567
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protein ubiquitination
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GO:0038018
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Wnt receptor catabolic process
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GO:0072089
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stem cell proliferation
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GO:0090090
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negative regulation of canonical Wnt signaling pathway
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GO:2000051
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negative regulation of non-canonical Wnt signaling pathway
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Cellular Component |
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PDB ID |
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InterPro |
IPR001841
Zinc finger, RING-type
IPR018957
Zinc finger, C3HC4 RING-type
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PFAM |
PF13639
PF14634
PF00097
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PRINTS |
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PIRSF |
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SMART |
SM00184
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TIGRFAMs |
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Modification |
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SwissProt |
Q9ULT6
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PhosphoSite |
PhosphoSite-Q9ULT6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
84133
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UniGene |
Hs.732114
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RefSeq |
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HUGO |
HGNC:18126
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OMIM |
612062
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CCDS |
CCDS42999
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HPRD |
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IMGT |
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EMBL |
AB051436
AK096397
AL021393
AL031596
BC021570
BC069019
BC094857
CR456397
Z95113
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GenPept |
AAH21570
AAH69019
AAH94857
BAB33319
BAG53280
CAG30283
CAI17901
CAI17992
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