InnateDB Protein
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IDBP-294826.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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BRDT
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Protein Name
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bromodomain, testis-specific
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Synonyms
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BRD6; CT9;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000384051
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InnateDB Gene
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IDBG-100249 (BRDT)
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Protein Structure
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Function |
Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids. Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin. {ECO:0000269PubMed:15647849, ECO:0000269PubMed:22901802, ECO:0000269PubMed:9367677}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:20538714, ECO:0000269PubMed:22901802, ECO:0000269PubMed:22971749}. Note=Detected on chromatin.
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Disease Associations |
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Tissue Specificity |
Testis-specific. A 3-fold higher expression is seen in adult testis than in embryo testis. Expression seems to be correlated with histone H4 hyperacetylation during the haploid phase of spermatogenesis (spermiogenesis). No expression, or very low expression is seen in patients' testes with abnormal spermatogenesis. Expressed in cancers such as non-small cell lung cancer and squamous cell carcinomas of the head and neck as well as of esophagus, but not in melanoma or in cancers of the colon, breast, kidney and bladder. {ECO:0000269PubMed:10704737, ECO:0000269PubMed:15647849, ECO:0000269PubMed:9367677}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001487
Bromodomain
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PFAM |
PF00439
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PRINTS |
PR00503
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PIRSF |
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SMART |
SM00297
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TIGRFAMs |
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Modification |
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SwissProt |
Q58F21
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PhosphoSite |
PhosphoSite-Q58F21
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TrEMBL |
F8W0H2
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UniProt Splice Variant |
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Entrez Gene |
676
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UniGene |
Hs.739345
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RefSeq |
NP_001717
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HUGO |
HGNC:1105
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OMIM |
602144
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CCDS |
CCDS735
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HPRD |
03684
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IMGT |
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EMBL |
AC114486
AF019085
AK302758
AK303008
AK316442
AY338951
BC005281
BC017582
BC047900
BC062700
CH471097
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GenPept |
AAB87862
AAH05281
AAH17582
AAH47900
AAH62700
AAQ16198
BAH13797
BAH13876
BAH14813
EAW73106
EAW73107
EAW73108
EAW73110
EAW73111
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