InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KIF16B

Summary

InnateDB Protein

IDBP-294865.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIF16B

Protein Name

kinesin family member 16B

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000384164

InnateDB Gene

IDBG-55302 (KIF16B)

Protein Structure

UniProt Annotation

Function

Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. {ECO:0000269PubMed:15882625}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000305}. Early endosome membrane. Note=It is unclear whether association with endosomes is mediated via phosphatidylinositol 3-phosphate (PtdIns(3)P)-binding or via its interaction with RAB14.

Disease Associations

Tissue Specificity

Primarily expressed in brain. Also present in kidney, liver, intestine, placenta, leukocytes, heart and skeletal muscle (at protein level). {ECO:0000269PubMed:15882625}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008017	microtubule binding
GO:0008574	plus-end-directed microtubule motor activity
GO:0017137	Rab GTPase binding
GO:0032266	phosphatidylinositol-3-phosphate binding
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding

Biological Process

GO:0001704	formation of primary germ layer
GO:0001919	regulation of receptor recycling
GO:0006895	Golgi to endosome transport
GO:0007018	microtubule-based movement
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007492	endoderm development
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0032801	receptor catabolic process
GO:0045022	early endosome to late endosome transport

Cellular Component

GO:0005768	endosome
GO:0005769	early endosome
GO:0005871	kinesin complex
GO:0005874	microtubule
GO:0031901	early endosome membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000253 Forkhead-associated (FHA) domain
IPR001752 Kinesin, motor domain
IPR008984 SMAD/FHA domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029071 Ubiquitin-related domain

PFAM

PF00498
PF00225

PRINTS

PR00380

PIRSF

SMART

SM00240
SM00129

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt