InnateDB Protein
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IDBP-294926.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TCEB2
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Protein Name
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transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
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Synonyms
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ELOB; SIII;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000386652
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InnateDB Gene
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IDBG-10956 (TCEB2)
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Protein Structure
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Function |
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC- box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 158 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated |
Total |
158
[view]
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Protein-Protein |
158
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
11 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000626
Ubiquitin-like
IPR029071
Ubiquitin-related domain
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PFAM |
PF00240
PF14560
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PRINTS |
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PIRSF |
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SMART |
SM00213
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TIGRFAMs |
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Modification |
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SwissProt |
Q15370
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PhosphoSite |
PhosphoSite-Q15370
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TrEMBL |
B8ZZU8
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UniProt Splice Variant |
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Entrez Gene |
6923
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UniGene |
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RefSeq |
NP_009039
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HUGO |
HGNC:11619
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OMIM |
600787
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CCDS |
CCDS45387
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HPRD |
02874
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IMGT |
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EMBL |
AC004493
AC092117
BC013306
BC065000
BM700019
CH471112
L42856
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GenPept |
AAA75522
AAC08452
AAH13306
AAH65000
EAW85472
EAW85473
EAW85474
EAW85476
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