Version 5.4
Homo sapiens Protein: PUM2
Summary
InnateDB Protein IDBP-294991.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PUM2
Protein Name pumilio homolog 2 (Drosophila)
Synonyms PUMH2; PUML2;
Species Homo sapiens
Ensembl Protein ENSP00000385992
InnateDB Gene IDBG-32267 (PUM2)
Protein Structure
UniProt Annotation
Function Sequence-specific RNA-binding protein that negatively regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). Capable of deadenylation-dependent and -independent modes of repression. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts. {ECO:0000269PubMed:21397187, ECO:0000269PubMed:22955276}.
Subcellular Localization Cytoplasm {ECO:0000305PubMed:19168546}. Cytoplasmic granule {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000269PubMed:19168546}. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). Colocalizes with NANOS1 and SNAPIN in the perinuclear region of germ cells. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in male germ cells of adult testis (at protein level). Highly expressed in testis and ovary. Predominantly expressed in stem cells and germ cells. Expressed at lower level in brain, heart, kidney, liver, muscle, placenta, intestine and stomach Expressed in cerebellum, corpus callosum, caudate nucleus, hippocampus, medulla oblongata and putamen. Expressed in all fetal tissues tested. {ECO:0000269PubMed:12459267, ECO:0000269PubMed:12511597, ECO:0000269PubMed:19168546}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 3 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005488 binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006417 regulation of translation
Cellular Component
GO:0005737 cytoplasm
GO:0010494 cytoplasmic stress granule
GO:0031965 nuclear membrane
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001313 Pumilio RNA-binding repeat
IPR016024 Armadillo-type fold
PFAM PF00806
PRINTS
PIRSF
SMART SM00025
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TB72
PhosphoSite PhosphoSite-Q8TB72
TrEMBL C9JW01
UniProt Splice Variant
Entrez Gene 23369
UniGene Hs.713755
RefSeq
HUGO HGNC:14958
OMIM 607205
CCDS CCDS1698
HPRD 09527
IMGT
EMBL AC007041 AF272350 AF315591 AK093847 AK304198 BC024218 BC112046 BC112048 CH471053 D87078
GenPept AAG31806 AAH24218 AAI12047 AAI12049 AAL36981 AAY15026 BAA19665 BAG52772 BAG65078 EAX00821 EAX00823

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca