InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CBLB

Summary

InnateDB Protein

IDBP-295264.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CBLB

Protein Name

Cas-Br-M (murine) ecotropic retroviral transforming sequence b

Synonyms

Cbl-b; RNF56;

Species

Homo sapiens

Ensembl Protein

ENSP00000384938

InnateDB Gene

IDBG-48442 (CBLB)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	79 [view]
Protein-Protein	79 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001784	phosphotyrosine binding
GO:0004842	ubiquitin-protein transferase activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0016567	protein ubiquitination

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000980 SH2 domain
IPR001841 Zinc finger, RING-type
IPR003153 Adaptor protein Cbl, N-terminal helical
IPR014741 Adaptor protein Cbl, EF hand-like
IPR014742 Adaptor protein Cbl, SH2-like
IPR018957 Zinc finger, C3HC4 RING-type

PFAM