Homo sapiens Protein: CBLB | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-295266.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | CBLB | ||||||||||||||||||||||
Protein Name | Cas-Br-M (murine) ecotropic retroviral transforming sequence b | ||||||||||||||||||||||
Synonyms | Cbl-b; RNF56; | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000384816 | ||||||||||||||||||||||
InnateDB Gene | IDBG-48442 (CBLB) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B- cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T- cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. {ECO:0000269PubMed:10022120, ECO:0000269PubMed:10086340, ECO:0000269PubMed:11087752, ECO:0000269PubMed:11526404, ECO:0000269PubMed:14661060, ECO:0000269PubMed:20525694}. | ||||||||||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000269PubMed:12177062}. Note=Upon EGF stimulation, associates with endocytic vesicles. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Expressed in placenta, heart, lung, kidney, spleen, ovary and testis, as well as fetal brain and liver and hematopoietic cell lines, but not in adult brain, liver, pancreas, salivary gland, or skeletal muscle. Present in lymphocytes (at protein level). {ECO:0000269PubMed:10022120, ECO:0000269PubMed:9399639}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR000980
SH2 domain IPR001841 Zinc finger, RING-type IPR003153 Adaptor protein Cbl, N-terminal helical IPR014741 Adaptor protein Cbl, EF hand-like IPR014742 Adaptor protein Cbl, SH2-like IPR018957 Zinc finger, C3HC4 RING-type |
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PFAM |
PF00017
PF14633 PF13639 PF14634 PF02262 PF02761 PF02762 PF00097 |
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PRINTS |
PR00401
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PIRSF | |||||||||||||||||||||||
SMART |
SM00252
SM00184 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q13191 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q13191 | ||||||||||||||||||||||
TrEMBL | C9JU85 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 868 | ||||||||||||||||||||||
UniGene | Hs.622985 | ||||||||||||||||||||||
RefSeq | |||||||||||||||||||||||
HUGO | HGNC:1542 | ||||||||||||||||||||||
OMIM | 604491 | ||||||||||||||||||||||
CCDS | |||||||||||||||||||||||
HPRD | 05136 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AB075490 AC016138 AC112485 AC126185 AK292792 BC032851 BX537484 CH471052 DQ349203 U26710 U26711 U26712 | ||||||||||||||||||||||
GenPept | AAB09291 AAB09292 AAB09293 AAH32851 ABC86700 BAE45748 BAF85481 CAH56175 EAW79752 EAW79753 EAW79754 | ||||||||||||||||||||||