InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPARGC1B

Summary

InnateDB Protein

IDBP-295296.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPARGC1B

Protein Name

peroxisome proliferator-activated receptor gamma, coactivator 1 beta

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000384403

InnateDB Gene

IDBG-53101 (PPARGC1B)

Protein Structure

UniProt Annotation

Function

Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. {ECO:0000269PubMed:11854298, ECO:0000269PubMed:12678921, ECO:0000269PubMed:15546003, ECO:0000269PubMed:23836911}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11854298}.

Disease Associations

Tissue Specificity

Ubiquitous with higher expression in heart, brain and skeletal muscle. {ECO:0000269PubMed:11854298, ECO:0000269PubMed:12678921}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	5 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0030331	estrogen receptor binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0030546	receptor activator activity
GO:0050682	AF-2 domain binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:2000273	positive regulation of receptor activity