InnateDB Protein
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IDBP-295340.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NRG3
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Protein Name
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neuregulin 3
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Synonyms
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HRG3; pro-NRG3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000384796
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InnateDB Gene
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IDBG-80642 (NRG3)
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Protein Structure
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Function |
Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes. {ECO:0000269PubMed:16478787, ECO:0000269PubMed:9275162}.
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Subcellular Localization |
Pro-neuregulin-3, membrane-bound isoform: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Does not seem to be active. {ECO:0000250}.Neuregulin-3: Secreted {ECO:0000250}.Isoform 3: Cell membrane; Single-pass type I membrane protein. Note=Isoform 3 is also proteolytically released as a soluble form.
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Disease Associations |
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Tissue Specificity |
Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0001558
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regulation of cell growth
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GO:0007171
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activation of transmembrane receptor protein tyrosine kinase activity
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Cellular Component |
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PDB ID |
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InterPro |
IPR000742
Epidermal growth factor-like domain
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PFAM |
PF00008
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PRINTS |
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PIRSF |
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SMART |
SM00181
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TIGRFAMs |
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Modification |
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SwissProt |
P56975
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PhosphoSite |
PhosphoSite-P56975
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TrEMBL |
D9ZHP6
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UniProt Splice Variant |
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Entrez Gene |
10718
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UniGene |
Hs.125119
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RefSeq |
XP_005269501
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HUGO |
HGNC:7999
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OMIM |
605533
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CCDS |
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HPRD |
16115
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IMGT |
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EMBL |
AL096706
AL136085
AL354749
AL391478
AL513204
AL589782
DQ001411
DQ857894
HM068873
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GenPept |
AAY17216
ABG77979
ADK90020
CAH70641
CAH71050
CAH73645
CAI15622
CAI17213
CAI22410
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