InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHKB

Summary

InnateDB Protein

IDBP-295520.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHKB

Protein Name

choline kinase beta

Synonyms

CHETK; CHKL; CK; CKB; CKEKB; EK; EKB; MDCMC;

Species

Homo sapiens

Ensembl Protein

ENSP00000384400

InnateDB Gene

IDBG-13907 (CHKB)

Protein Structure

UniProt Annotation

Function

Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis. {ECO:0000269PubMed:19915674}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004103	choline kinase activity
GO:0004305	ethanolamine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006646	phosphatidylethanolamine biosynthetic process
GO:0006656	phosphatidylcholine biosynthetic process
GO:0006657	CDP-choline pathway
GO:0008152	metabolic process
GO:0016310	phosphorylation
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process