InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD207

Summary

InnateDB Protein

IDBP-295615.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD207

Protein Name

CD207 molecule, langerin

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000386378

InnateDB Gene

IDBG-55659 (CD207)

Protein Structure

UniProt Annotation

Function

Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation. {ECO:0000269PubMed:10661407, ECO:0000269PubMed:17334373, ECO:0000269PubMed:20026605, ECO:0000269PubMed:20097424}.

Subcellular Localization

Membrane {ECO:0000269PubMed:10661407}; Single-pass type II membrane protein {ECO:0000269PubMed:10661407}. Note=Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.

Disease Associations

Birbeck granule deficiency (BIRGD) [MIM:613393]: A condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules, Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity. {ECO:0000269PubMed:15816828}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues. {ECO:0000269PubMed:10661407, ECO:0000269PubMed:20026605}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005537	mannose binding
GO:0030246	carbohydrate binding

Biological Process

GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0051607	defense response to virus

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030139	endocytic vesicle
GO:0030669	clathrin-coated endocytic vesicle membrane
GO:0031901	early endosome membrane