InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARHGAP25

Summary

InnateDB Protein

IDBP-295690.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGAP25

Protein Name

Rho GTPase activating protein 25

Synonyms

HEL-S-308; KAIA0053;

Species

Homo sapiens

Ensembl Protein

ENSP00000386911

InnateDB Gene

IDBG-54649 (ARHGAP25)

Protein Structure

UniProt Annotation

Function

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000198 Rho GTPase-activating protein domain
IPR001849 Pleckstrin homology domain
IPR008936 Rho GTPase activation protein

PFAM

PF00620
PF00169

PRINTS

PIRSF

SMART

SM00324
SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P42331

PhosphoSite

PhosphoSite-P42331

TrEMBL

C9JB56

UniProt Splice Variant

Entrez Gene

9938

UniGene

Hs.740143

RefSeq

NP_001007232

HUGO

HGNC:28951

OMIM

610587

CCDS

CCDS33214

HPRD

09805

IMGT

EMBL

AC097495 AC105054 AC112700 AK290396 AK297056 BC039591 CH471053 D29642

GenPept

AAH39591 BAA06125 BAF83085 BAH12484 EAW99866