InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAP1GDS1

Summary

InnateDB Protein

IDBP-295722.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAP1GDS1

Protein Name

RAP1, GTP-GDP dissociation stimulator 1

Synonyms

GDS1; SmgGDS;

Species

Homo sapiens

Ensembl Protein

ENSP00000386223

InnateDB Gene

IDBG-30852 (RAP1GDS1)

Protein Structure

UniProt Annotation

Function

Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	42 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005488	binding
GO:0005515	protein binding
GO:0046961	proton-transporting ATPase activity, rotational mechanism

Biological Process

GO:0015991	ATP hydrolysis coupled proton transport
GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration
GO:0051561	positive regulation of mitochondrial calcium ion concentration

Cellular Component

GO:0000221	vacuolar proton-transporting V-type ATPase, V1 domain
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome