InnateDB Protein
|
IDBP-29712.5
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
STX8
|
Protein Name
|
syntaxin 8
|
Synonyms
|
CARB;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000305255
|
InnateDB Gene
|
IDBG-29710 (STX8)
|
Protein Structure
|
|
Function |
Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.
|
Subcellular Localization |
Membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Note=Preferentially associated with the early endosome. To lesser extends, also present in late endosome, the plasma membrane and coated pits (By similarity). {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Highly expressed in heart. Also found in brain, kidney, liver, lung, placenta, skeletal muscle, spleen and pancreas.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
26
[view]
|
Protein-Protein |
26
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
3 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000727
Target SNARE coiled-coil domain
|
PFAM |
PF05739
|
PRINTS |
|
PIRSF |
|
SMART |
SM00397
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9UNK0
|
PhosphoSite |
PhosphoSite-Q9UNK0
|
TrEMBL |
K7EQB1
|
UniProt Splice Variant |
|
Entrez Gene |
9482
|
UniGene |
|
RefSeq |
NP_004844
|
HUGO |
HGNC:11443
|
OMIM |
604203
|
CCDS |
CCDS32565
|
HPRD |
05012
|
IMGT |
|
EMBL |
AC005695
AC009335
AC087501
AF036715
AF062077
AF115323
BC009713
BT007319
CH471108
|
GenPept |
AAC36466
AAC95285
AAD20831
AAH09713
AAP35983
EAW90029
|
|
|