InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LALBA

Summary

InnateDB Protein

IDBP-30145.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LALBA

Protein Name

lactalbumin, alpha-

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000301046

InnateDB Gene

IDBG-30143 (LALBA)

Protein Structure

UniProt Annotation

Function

Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Mammary gland specific. Secreted in milk.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004461	lactose synthase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0005989	lactose biosynthetic process
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0042742	defense response to bacterium