InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IQGAP1

Summary

InnateDB Protein

IDBP-30206.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IQGAP1

Protein Name

IQ motif containing GTPase activating protein 1

Synonyms

HUMORFA01; p195; SAR1;

Species

Homo sapiens

Ensembl Protein

ENSP00000268182

InnateDB Gene

IDBG-30204 (IQGAP1)

Protein Structure

UniProt Annotation

Function

Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth. {ECO:0000269PubMed:15695813}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:15355962}.

Disease Associations

Tissue Specificity

Expressed in the placenta, lung, and kidney. A lower level expression is seen in the heart, liver, skeletal muscle and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 161 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	161 [view]
Protein-Protein	161 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005095	GTPase inhibitor activity
GO:0005096	GTPase activator activity
GO:0005099	Ras GTPase activator activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0017048	Rho GTPase binding
GO:0019901	protein kinase binding
GO:0019903	protein phosphatase binding
GO:0032403	protein complex binding
GO:0043539	protein serine/threonine kinase activator activity
GO:0048365	Rac GTPase binding

Biological Process

GO:0001817	regulation of cytokine production
GO:0006112	energy reserve metabolic process
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0032320	positive regulation of Ras GTPase activity
GO:0035305	negative regulation of dephosphorylation
GO:0043086	negative regulation of catalytic activity
GO:0043547	positive regulation of GTPase activity
GO:0044281	small molecule metabolic process
GO:0045860	positive regulation of protein kinase activity
GO:0050796	regulation of insulin secretion
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0071277	cellular response to calcium ion
GO:0071364	cellular response to epidermal growth factor stimulus
GO:0071902	positive regulation of protein serine/threonine kinase activity
GO:0072015	glomerular visceral epithelial cell development

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005874	microtubule
GO:0005884	actin filament
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0016328	lateral plasma membrane
GO:0030054	cell junction
GO:0030496	midbody
GO:0030529	ribonucleoprotein complex
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0031252	cell leading edge
GO:0036057	slit diaphragm
GO:0036464	cytoplasmic ribonucleoprotein granule
GO:0043005	neuron projection
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR000593 RasGAP protein, C-terminal
IPR001202 WW domain
IPR001715 Calponin homology domain
IPR001936 Ras GTPase-activating protein
IPR008936 Rho GTPase activation protein
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF03836
PF00397
PF00307
PF00616

PRINTS

PIRSF

SMART

SM00015
SM00456
SM00033
SM00323

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P46940