InnateDB Protein
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IDBP-30414.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NLRP10
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Protein Name
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NLR family, pyrin domain containing 10
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000327763
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InnateDB Gene
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IDBG-30412 (NLRP10)
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Protein Structure
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Function |
Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID. Displays anti-inflammatory activity. Plays a role in adaptive immunity through control of dendritic cell-mediated transport of antigen to the lymph nodes from peripheral sites. Required for immunity against C.albicans infection. Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection. {ECO:0000269PubMed:15096476, ECO:0000269PubMed:20393137, ECO:0000269PubMed:22672233}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:22672233}. Cell membrane {ECO:0000269PubMed:22672233}. Note=Cytoplasmic protein which is recruited to the cell membrane by NOD1 following invasive bacterial infection.
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Disease Associations |
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Tissue Specificity |
Highly expressed in basal and suprabasal epidermal cell layers with lower levels in dermal fibroblast cells (at protein level). Widely expressed with highest levels in heart, brain and skeletal muscle. Also expressed in liver, colon, dermis and epidermis. Little expression detected in myeloid cells or peripheral blood mononuclear cells. {ECO:0000269PubMed:15096476, ECO:0000269PubMed:22672233}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0002827
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positive regulation of T-helper 1 type immune response
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GO:0035397
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helper T cell enhancement of adaptive immune response
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GO:0036336
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dendritic cell migration
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GO:0045087
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innate immune response (InnateDB)
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GO:0050829
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defense response to Gram-negative bacterium
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GO:0050832
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defense response to fungus
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GO:2000318
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positive regulation of T-helper 17 type immune response
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GO:2000484
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positive regulation of interleukin-8 secretion
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GO:2000778
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positive regulation of interleukin-6 secretion
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Cellular Component |
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PDB ID |
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InterPro |
IPR004020
DAPIN domain
IPR007111
NACHT nucleoside triphosphatase
IPR011029
Death-like domain
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF02758
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q86W26
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PhosphoSite |
PhosphoSite-Q86W26
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TrEMBL |
E9PPY0
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UniProt Splice Variant |
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Entrez Gene |
338322
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UniGene |
Hs.694552
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RefSeq |
NP_789791
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HUGO |
HGNC:21464
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OMIM |
609662
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CCDS |
CCDS7784
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HPRD |
14802
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IMGT |
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EMBL |
AC044810
AY154465
AY489192
BC104957
BK001110
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GenPept |
AAI04958
AAO18161
AAS67384
DAA01243
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