Version 5.4
Homo sapiens Protein: COPS6
Summary
InnateDB Protein IDBP-30499.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COPS6
Protein Name COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)
Synonyms CSN6; MOV34-34KD;
Species Homo sapiens
Ensembl Protein ENSP00000304102
InnateDB Gene IDBG-30497 (COPS6)
Protein Structure
UniProt Annotation
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor- responsive activity. Stabilizes RFWD2/COP1 through reducing RFWD2 auto-ubiquitination and decelerating RFWD2 turnover rate, hence regulates the ubiquitination of RFWD2 targets. {ECO:0000269PubMed:11285227, ECO:0000269PubMed:11337588, ECO:0000269PubMed:12628923, ECO:0000269PubMed:12732143, ECO:0000269PubMed:21625211, ECO:0000269PubMed:9535219}.
Subcellular Localization Nucleus. Cytoplasm. Note=The interaction with HIV-1 Vpr protein possibly leads its translocation to a perinuclear region.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:9520381}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 338 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 338 [view]
Protein-Protein 338 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0010388 cullin deneddylation
GO:0016032 viral process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0008180 COP9 signalosome
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000555 JAB1/MPN/MOV34 metalloenzyme domain
PFAM PF01398
PRINTS
PIRSF
SMART SM00232
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7L5N1
PhosphoSite PhosphoSite-Q7L5N1
TrEMBL C9JQK5
UniProt Splice Variant
Entrez Gene 10980
UniGene
RefSeq NP_006824
HUGO HGNC:21749
OMIM 614729
CCDS CCDS5682
HPRD 16735
IMGT
EMBL AC073842 AK312024 BC002520 CH236956 CH471091 U70735
GenPept AAD03469 AAH02520 BAG34961 EAL23857 EAW76601

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca