Version 5.4
Homo sapiens Protein: RIC3
Summary
InnateDB Protein IDBP-30549.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RIC3
Protein Name resistance to inhibitors of cholinesterase 3 homolog (C. elegans)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000308820
InnateDB Gene IDBG-30545 (RIC3)
Protein Structure
UniProt Annotation
Function Promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface. May also promote functional expression of homomeric serotoninergic 5- HT3 receptors, and of heteromeric acetylcholine receptors alpha- 3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4. {ECO:0000269PubMed:12821669, ECO:0000269PubMed:15504725, ECO:0000269PubMed:15809299, ECO:0000269PubMed:15927954, ECO:0000269PubMed:16120769, ECO:0000269PubMed:17609200, ECO:0000269PubMed:18691158}.
Subcellular Localization Isoform 1: Endoplasmic reticulum membrane; Single-pass membrane protein.Isoform 2: Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single- pass membrane protein.
Disease Associations
Tissue Specificity Broadly expressed, with high levels in muscle, brain, heart, pancreas and testis. In the central nervous system, highest levels are detected in the cerebellum and pituitary gland. Over-expressed in brains from patients with bipolar disease or schizophrenia. Isoform 5 is predominantly expressed in the brain. {ECO:0000269PubMed:12821669, ECO:0000269PubMed:17640815, ECO:0000269PubMed:18691158}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0033130 acetylcholine receptor binding
GO:0044183 protein binding involved in protein folding
Biological Process
GO:0006457 protein folding
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007271 synaptic transmission, cholinergic
GO:0043623 cellular protein complex assembly
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7Z5B4
PhosphoSite PhosphoSite-Q7Z5B4
TrEMBL F5GZ89
UniProt Splice Variant
Entrez Gene 79608
UniGene Hs.231850
RefSeq NP_001193600
HUGO HGNC:30338
OMIM 610509
CCDS CCDS55742
HPRD 17974
IMGT
EMBL AC091013 AC116456 AC129895 AK021670 AK315379 AL832601 AM422214 AY326435 AY326436 AY358475 BC022455 CH471064
GenPept AAH22455 AAP92162 AAP92163 AAQ88839 BAB13871 BAG37772 CAD89943 CAM12309 EAW68628 EAW68630

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca