InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TDGF1

Summary

InnateDB Protein

IDBP-30593.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TDGF1

Protein Name

teratocarcinoma-derived growth factor 1

Synonyms

CR; CRGF; CRIPTO;

Species

Homo sapiens

Ensembl Protein

ENSP00000296145

InnateDB Gene

IDBG-409017 (TDGF1)

Protein Structure

UniProt Annotation

Function

Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. {ECO:0000269PubMed:11909953}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:18930707}; Lipid-anchor, GPI-anchor {ECO:0000269PubMed:18930707}.

Disease Associations

Tissue Specificity

Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung. {ECO:0000269PubMed:18835250}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0000187	activation of MAPK activity
GO:0001570	vasculogenesis
GO:0001701	in utero embryonic development
GO:0001763	morphogenesis of a branching structure
GO:0001954	positive regulation of cell-matrix adhesion
GO:0002042	cell migration involved in sprouting angiogenesis
GO:0007369	gastrulation
GO:0007507	heart development
GO:0008284	positive regulation of cell proliferation
GO:0008595	anterior/posterior axis specification, embryo
GO:0009790	embryo development
GO:0009948	anterior/posterior axis specification
GO:0009966	regulation of signal transduction
GO:0010595	positive regulation of endothelial cell migration
GO:0018105	peptidyl-serine phosphorylation
GO:0030154	cell differentiation
GO:0030334	regulation of cell migration
GO:0030335	positive regulation of cell migration
GO:0030509	BMP signaling pathway
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030879	mammary gland development
GO:0035729	cellular response to hepatocyte growth factor stimulus
GO:0043066	negative regulation of apoptotic process
GO:0044344	cellular response to fibroblast growth factor stimulus
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048146	positive regulation of fibroblast proliferation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0055007	cardiac muscle cell differentiation
GO:0060070	canonical Wnt signaling pathway
GO:0071346	cellular response to interferon-gamma
GO:0071354	cellular response to interleukin-6
GO:0071356	cellular response to tumor necrosis factor
GO:0071364	cellular response to epidermal growth factor stimulus

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0009986	cell surface
GO:0016324	apical plasma membrane
GO:0019897	extrinsic component of plasma membrane
GO:0031225	anchored component of membrane
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm