InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: YWHAZ

Summary

InnateDB Protein

IDBP-30921.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

YWHAZ

Protein Name

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

Synonyms

14-3-3-zeta; HEL-S-3; HEL4; KCIP-1; YWHAD;

Species

Homo sapiens

Ensembl Protein

ENSP00000309503

InnateDB Gene

IDBG-30919 (YWHAZ)

Protein Structure

UniProt Annotation

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. {ECO:0000269PubMed:14578935, ECO:0000269PubMed:15071501, ECO:0000269PubMed:15644438, ECO:0000269PubMed:16376338, ECO:0000269PubMed:9360956}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:17081065}. Melanosome {ECO:0000269PubMed:17081065}. Note=Located to stage I to stage IV melanosomes.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 769 experimentally validated interaction(s) in this database.
They are also associated with 155 interaction(s) predicted by orthology.

Experimentally validated
Total	769 [view]
Protein-Protein	767 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	155 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0016301	kinase activity
GO:0019901	protein kinase binding
GO:0019904	protein domain specific binding
GO:0042802	identical protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0016310	phosphorylation
GO:0030168	platelet activation
GO:0043066	negative regulation of apoptotic process
GO:0061024	membrane organization
GO:0097193	intrinsic apoptotic signaling pathway
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030659	cytoplasmic vesicle membrane
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle