InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAST1

Summary

InnateDB Protein

IDBP-31159.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAST1

Protein Name

microtubule associated serine/threonine kinase 1

Synonyms

SAST; SAST170;

Species

Homo sapiens

Ensembl Protein

ENSP00000251472

InnateDB Gene

IDBG-31157 (MAST1)

Protein Structure

UniProt Annotation

Function

Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity). {ECO:0000250UniProtKB:Q9R1L5}.

Subcellular Localization

Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalizes with syntrophins at the cell membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	36 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007010	cytoskeleton organization
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001478 PDZ domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR015022 Microtubule-associated serine/threonine-protein kinase, domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR023142 Microtubule-associated serine/threonine-protein kinase, pre-PK domain

PFAM

PF00069
PF07714
PF00595
PF13180
PF08926

PRINTS

PR00109

PIRSF

SMART

SM00228
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt