Version 5.4
Homo sapiens Protein: DNASE2
Summary
InnateDB Protein IDBP-31204.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNASE2
Protein Name deoxyribonuclease II, lysosomal
Synonyms DNASE2A; DNL; DNL2;
Species Homo sapiens
Ensembl Protein ENSP00000222219
InnateDB Gene IDBG-31202 (DNASE2)
Protein Structure
UniProt Annotation
Function Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.
Subcellular Localization Lysosome.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004520 endodeoxyribonuclease activity
GO:0004531 deoxyribonuclease II activity
Biological Process
GO:0006259 DNA metabolic process
GO:0006308 DNA catabolic process
GO:0006309 apoptotic DNA fragmentation
GO:0030218 erythrocyte differentiation
Cellular Component
GO:0005622 intracellular
GO:0005764 lysosome
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR004947 Deoxyribonuclease II
PFAM PF03265
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O00115
PhosphoSite PhosphoSite-O00115
TrEMBL A0A024R7F4
UniProt Splice Variant
Entrez Gene 1777
UniGene Hs.118243
RefSeq NP_001366
HUGO HGNC:2960
OMIM 126350
CCDS CCDS12284
HPRD 00531
IMGT
EMBL AB004574 AB008564 AD000092 AF045937 AF047016 AF060222 AK315358 BC010419 BC065209 BT007047 CH471106
GenPept AAB51172 AAC35751 AAC39852 AAC77366 AAH10419 AAH65209 AAP35696 BAA28623 BAB55598 BAG37753 EAW84320 EAW84322

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca