InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MEPCE

Summary

InnateDB Protein

IDBP-31257.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MEPCE

Protein Name

methylphosphate capping enzyme

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000308546

InnateDB Gene

IDBG-31255 (MEPCE)

Protein Structure

UniProt Annotation

Function

S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to stabilize it. {ECO:0000269PubMed:17643375}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in chronic myeloid leukemia cells, adrenal gland, brain, cerebellum, kidney, lung, mammary gland and testis. Weakly or not expressed in other tissues. {ECO:0000269PubMed:12358911}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 178 experimentally validated interaction(s) in this database.

Experimentally validated
Total	178 [view]
Protein-Protein	175 [view]
Protein-DNA	1 [view]
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008168	methyltransferase activity
GO:0008173	RNA methyltransferase activity
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001510	RNA methylation
GO:0016073	snRNA metabolic process
GO:0035562	negative regulation of chromatin binding
GO:0040031	snRNA modification
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle