InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HS3ST3A1

Summary

InnateDB Protein

IDBP-31323.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HS3ST3A1

Protein Name

heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1

Synonyms

30ST3A1; 3OST3A1;

Species

Homo sapiens

Ensembl Protein

ENSP00000284110

InnateDB Gene

IDBG-31321 (HS3ST3A1)

Protein Structure

UniProt Annotation

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N- unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non- anticoagulant heparan sulfate to anticoagulant heparan sulfate. {ECO:0000269PubMed:10520990}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitous. Most abundant in heart and placenta, followed by liver and kidney. {ECO:0000269PubMed:9988767}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008146	sulfotransferase activity
GO:0033872	[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006024	glycosaminoglycan biosynthetic process
GO:0008152	metabolic process
GO:0030203	glycosaminoglycan metabolic process
GO:0044281	small molecule metabolic process