InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WEE1

Summary

InnateDB Protein

IDBP-31417.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WEE1

Protein Name

WEE1 homolog (S. pombe)

Synonyms

WEE1A; WEE1hu;

Species

Homo sapiens

Ensembl Protein

ENSP00000299613

InnateDB Gene

IDBG-31415 (WEE1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.

Experimentally validated
Total	38 [view]
Protein-Protein	36 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006468	protein phosphorylation
GO:0007067	mitotic nuclear division
GO:0007596	blood coagulation
GO:0051726	regulation of cell cycle

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR017164 Wee1-like protein kinase
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

PIRSF037281

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References