InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCNS3

Summary

InnateDB Protein

IDBP-31541.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNS3

Protein Name

potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3

Synonyms

KV9.3;

Species

Homo sapiens

Ensembl Protein

ENSP00000305824

InnateDB Gene

IDBG-31537 (KCNS3)

Protein Structure

UniProt Annotation

Function

Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1.

Disease Associations

Tissue Specificity

Detected in whole normal term placental and placental chorionic plate arteries and veins. Detected in syncytiotrophoblast and in blood vessel endothelium within intermediate villi and chorionic plate (at protein level). Detected in most tissues, but not in peripheral blood lymphocytes. The highest levels of expression are in lung. {ECO:0000269PubMed:22943705}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005251	delayed rectifier potassium channel activity
GO:0005515	protein binding
GO:0015459	potassium channel regulator activity

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0007268	synaptic transmission
GO:0034765	regulation of ion transmembrane transport
GO:0044281	small molecule metabolic process
GO:0050796	regulation of insulin secretion
GO:0051260	protein homooligomerization
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000210 BTB/POZ-like
IPR003091 Potassium channel
IPR003131 Potassium channel tetramerisation-type BTB domain
IPR003968 Potassium channel, voltage dependent, Kv
IPR003969 Potassium channel, voltage dependent, Kv6
IPR003971 Potassium channel, voltage dependent, Kv9
IPR003973 Potassium channel, voltage dependent, Kv2
IPR003974 Potassium channel, voltage dependent, Kv3
IPR005821 Ion transport domain
IPR011333 BTB/POZ fold
IPR013099 Two pore domain potassium channel domain

PFAM

PF02214
PF03521
PF00520
PF07885

PRINTS

PR00169
PR01491
PR01492
PR01494
PR01495
PR01498

PIRSF

SMART

SM00225

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt