InnateDB Protein
|
IDBP-32137.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
USP47
|
Protein Name
|
ubiquitin specific peptidase 47
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000339957
|
InnateDB Gene
|
IDBG-32135 (USP47)
|
Protein Structure
|
|
Function |
Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulates CDC25A expression at a transcriptional level. {ECO:0000269PubMed:19966869, ECO:0000269PubMed:21362556}.
|
Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:21362556}.
|
Disease Associations |
|
Tissue Specificity |
Expressed in skeletal muscle, heart and testis. {ECO:0000269PubMed:14715245}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
19
[view]
|
Protein-Protein |
19
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
GO:0006284
|
base-excision repair
|
GO:0006511
|
ubiquitin-dependent protein catabolic process
|
GO:0006974
|
cellular response to DNA damage stimulus
|
GO:0010972
|
negative regulation of G2/M transition of mitotic cell cycle
|
GO:0030307
|
positive regulation of cell growth
|
GO:0034644
|
cellular response to UV
|
GO:0035520
|
monoubiquitinated protein deubiquitination
|
GO:0042493
|
response to drug
|
GO:0043066
|
negative regulation of apoptotic process
|
GO:0043154
|
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
|
GO:0045892
|
negative regulation of transcription, DNA-templated
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001394
Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR028889
Ubiquitin carboxyl-terminal hydrolase-like domain
IPR029071
Ubiquitin-related domain
|
PFAM |
PF00443
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q96K76
|
PhosphoSite |
PhosphoSite-Q96K76
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
55031
|
UniGene |
Hs.619539
|
RefSeq |
NP_060414
|
HUGO |
HGNC:20076
|
OMIM |
614460
|
CCDS |
CCDS41619
|
HPRD |
|
IMGT |
|
EMBL |
AC104383
AC124276
AK000734
AK027362
AK074076
AK092290
AK127264
AL832991
BC000226
BC047044
|
GenPept |
AAH00226
AAH47044
BAA91348
BAB55063
BAB84902
BAG54467
CAH56337
|
|
|