Version 5.4
Homo sapiens Protein: TRIP6
Summary
InnateDB Protein IDBP-32243.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIP6
Protein Name thyroid hormone receptor interactor 6
Synonyms OIP-1; OIP1; TRIP-6; TRIP6i2; ZRP-1;
Species Homo sapiens
Ensembl Protein ENSP00000200457
InnateDB Gene IDBG-32241 (TRIP6)
Protein Structure
UniProt Annotation
Function Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor. {ECO:0000269PubMed:14688263, ECO:0000269PubMed:15489293, ECO:0000269PubMed:16624523, ECO:0000269PubMed:19017743}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000269PubMed:16624523}. Cell junction, focal adhesion {ECO:0000269PubMed:16624523}. Nucleus {ECO:0000269PubMed:16624523}. Cytoplasm {ECO:0000269PubMed:16624523}. Note=Shuttles between nucleus and cytoplasm.
Disease Associations
Tissue Specificity Abundantly expressed in kidney, liver and lung. Lower levels in heart, placenta and pancreas. Expressed in colonic epithelial cells. Up-regulated in colonic tumors. {ECO:0000269PubMed:19017743}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 123 experimentally validated interaction(s) in this database.
Experimentally validated
Total 126 [view]
Protein-Protein 124 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005149 interleukin-1 receptor binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019900 kinase binding
GO:0044822 poly(A) RNA binding
GO:0046966 thyroid hormone receptor binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008588 release of cytoplasmic sequestered NF-kappaB
GO:0030335 positive regulation of cell migration
GO:0048041 focal adhesion assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0045323 interleukin-1 receptor complex
Protein Structure and Domains
PDB ID
InterPro IPR001781 Zinc finger, LIM-type
PFAM PF00412
PRINTS
PIRSF
SMART SM00132
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15654
PhosphoSite PhosphoSite-Q15654
TrEMBL Q71V88
UniProt Splice Variant
Entrez Gene 7205
UniGene
RefSeq NP_003293
HUGO HGNC:12311
OMIM 602933
CCDS CCDS5708
HPRD 04242
IMGT
EMBL AB628086 AB628087 AC011895 AF000974 AF025437 AF093834 AF093835 AF093836 AF312032 AJ001902 AK291906 BC002680 BC004249 BC004999 BC021540 BC028985 CH236956 CH471091 L40374
GenPept AAB62222 AAC39557 AAC41740 AAD03037 AAH02680 AAH04249 AAH04999 AAH21540 AAH28985 AAK21007 BAF84595 BAK20497 BAK20498 CAA05080 EAL23817 EAW76472

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca