InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VCAN

Summary

InnateDB Protein

IDBP-32300.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VCAN

Protein Name

versican

Synonyms

CSPG2; ERVR; GHAP; PG-M; WGN; WGN1;

Species

Homo sapiens

Ensembl Protein

ENSP00000265077

InnateDB Gene

IDBG-32298 (VCAN)

Protein Structure

UniProt Annotation

Function

May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Wagner vitreoretinopathy (WGVRP) [MIM:143200]: A rare vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia. {ECO:0000269PubMed:16043844, ECO:0000269PubMed:22739342}. Note=The disease is caused by mutations affecting the gene represented in this entry. The pathological mechanism involves a quantitave imbalance of the normally occurring splice variants (PubMed:22739342). {ECO:0000269PubMed:22739342}.

Tissue Specificity

Cerebral white matter and plasma. Isoform V0 and isoform V1 are expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas. Isoform V2 is restricted to normal brain and gliomas. Isoform V3 is found in all these tissues except medulloblastomas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	34 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005539	glycosaminoglycan binding
GO:0005540	hyaluronic acid binding
GO:0030246	carbohydrate binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0005975	carbohydrate metabolic process
GO:0007155	cell adhesion
GO:0007275	multicellular organismal development
GO:0007507	heart development
GO:0008037	cell recognition
GO:0008347	glial cell migration
GO:0030198	extracellular matrix organization
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0030206	chondroitin sulfate biosynthetic process
GO:0030207	chondroitin sulfate catabolic process
GO:0030208	dermatan sulfate biosynthetic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005796	Golgi lumen
GO:0016020	membrane
GO:0031012	extracellular matrix
GO:0043202	lysosomal lumen
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR000436 Sushi/SCR/CCP
IPR000538 Link
IPR000742 Epidermal growth factor-like domain
IPR001304 C-type lectin
IPR001881 EGF-like calcium-binding domain
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR016187 C-type lectin fold

PFAM

PF00084
PF00193
PF00008
PF00059
PF07645
PF07686

PRINTS

PR01265

PIRSF

SMART

SM00032
SM00445
SM00181
SM00034
SM00179
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt