InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RSPO2

Summary

InnateDB Protein

IDBP-32365.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RSPO2

Protein Name

R-spondin 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000276659

InnateDB Gene

IDBG-32363 (RSPO2)

Protein Structure

UniProt Annotation

Function

Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors. {ECO:0000269PubMed:21727895, ECO:0000269PubMed:21909076, ECO:0000269PubMed:22615920}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0008201	heparin binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0016055	Wnt signaling pathway
GO:0030282	bone mineralization
GO:0035115	embryonic forelimb morphogenesis
GO:0035116	embryonic hindlimb morphogenesis
GO:0060437	lung growth
GO:0060441	epithelial tube branching involved in lung morphogenesis
GO:0060535	trachea cartilage morphogenesis
GO:0090263	positive regulation of canonical Wnt signaling pathway