InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EDIL3

Summary

InnateDB Protein

IDBP-32549.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EDIL3

Protein Name

EGF-like repeats and discoidin I-like domains 3

Synonyms

DEL1;

Species

Homo sapiens

Ensembl Protein

ENSP00000369483

InnateDB Gene

IDBG-32547 (EDIL3)

Protein Structure

UniProt Annotation

Function

Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0007275	multicellular organismal development
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0070062

extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000421 Coagulation factor 5/8 C-terminal type domain
IPR000742 Epidermal growth factor-like domain
IPR001881 EGF-like calcium-binding domain
IPR008979 Galactose-binding domain-like
IPR013111 EGF-like domain, extracellular

PFAM

PF00754
PF00008
PF07645
PF07974

PRINTS

PIRSF

SMART

SM00231
SM00181
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O43854