InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RFX1

Summary

InnateDB Protein

IDBP-32670.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RFX1

Protein Name

regulatory factor X, 1 (influences HLA class II expression)

Synonyms

EFC; RFX;

Species

Homo sapiens

Ensembl Protein

ENSP00000254325

InnateDB Gene

IDBG-32668 (RFX1)

Protein Structure

UniProt Annotation

Function

Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	20 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006955	immune response