InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NT5M

Summary

InnateDB Protein

IDBP-32947.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NT5M

Protein Name

5',3'-nucleotidase, mitochondrial

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000373674

InnateDB Gene

IDBG-32941 (NT5M)

Protein Structure

UniProt Annotation

Function

Dephosphorylates specifically the 5' and 2'(3')- phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP. {ECO:0000269PubMed:10899995}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:10899995}.

Disease Associations

Tissue Specificity

Highly expressed in heart, brain and skeletal muscle. Detected at very low levels in kidney and pancreas. {ECO:0000269PubMed:10899995}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0008252	nucleotidase activity
GO:0008253	5'-nucleotidase activity
GO:0046872	metal ion binding

Biological Process

GO:0006206	pyrimidine nucleobase metabolic process
GO:0006260	DNA replication
GO:0009223	pyrimidine deoxyribonucleotide catabolic process
GO:0009264	deoxyribonucleotide catabolic process
GO:0016311	dephosphorylation
GO:0044281	small molecule metabolic process
GO:0046079	dUMP catabolic process
GO:0046135	pyrimidine nucleoside catabolic process
GO:0055086	nucleobase-containing small molecule metabolic process