Version 5.4
Homo sapiens Protein: ARHGEF38
Summary
InnateDB Protein IDBP-32992.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGEF38
Protein Name Rho guanine nucleotide exchange factor (GEF) 38
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000265154
InnateDB Gene IDBG-304143 (ARHGEF38)
Protein Structure
UniProt Annotation
Function May act as a guanine-nucleotide releasing factor. {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0008603 cAMP-dependent protein kinase regulator activity
Biological Process
GO:0001932 regulation of protein phosphorylation
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005952 cAMP-dependent protein kinase complex
Protein Structure and Domains
PDB ID
InterPro IPR000219 Dbl homology (DH) domain
PFAM PF00621
PRINTS
PIRSF
SMART SM00325
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NXL2
PhosphoSite PhosphoSite-Q9NXL2
TrEMBL
UniProt Splice Variant
Entrez Gene 54848
UniGene Hs.743912
RefSeq NP_060170
HUGO HGNC:25968
OMIM
CCDS CCDS3670
HPRD 08613
IMGT
EMBL AC004066 AC105391 AK000191 BC105695 CH471057
GenPept AAI05696 BAA90998 EAX06187

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca