InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PEMT

Summary

InnateDB Protein

IDBP-33056.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PEMT

Protein Name

phosphatidylethanolamine N-methyltransferase

Synonyms

PEAMT; PEMPT; PEMT2; PNMT;

Species

Homo sapiens

Ensembl Protein

ENSP00000255389

InnateDB Gene

IDBG-33054 (PEMT)

Protein Structure

UniProt Annotation

Function

Catalyzes three sequential methylation reactions of phosphatidylethanolamine (PE) by AdoMet, thereby producing phosphatidylcholine (PC).

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Mitochondrion membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Found in endoplasmic reticulum where most PEMT activity is generated and in mitochondria. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000773	phosphatidyl-N-methylethanolamine N-methyltransferase activity
GO:0004608	phosphatidylethanolamine N-methyltransferase activity
GO:0008170	N-methyltransferase activity
GO:0080101	phosphatidyl-N-dimethylethanolamine N-methyltransferase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006644	phospholipid metabolic process
GO:0006656	phosphatidylcholine biosynthetic process
GO:0008283	cell proliferation
GO:0032259	methylation
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process