InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD97

Summary

InnateDB Protein

IDBP-33124.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD97

Protein Name

CD97 molecule

Synonyms

TM7LN1;

Species

Homo sapiens

Ensembl Protein

ENSP00000349918

InnateDB Gene

IDBG-33120 (CD97)

Protein Structure

UniProt Annotation

Function

Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.CD97 antigen subunit alpha: Secreted, extracellular space.

Disease Associations

Tissue Specificity

Broadly expressed, found on most hematopoietic cells, including activated lymphocytes, monocytes, macrophages, dendritic cells, and granulocytes. Expressed also abundantly by smooth muscle cells. Expressed in thyroid, colorectal, gastric, esophageal and pancreatic carcinomas too. Expression are increased under inflammatory conditions in the CNS of multiple sclerosis and in synovial tissue of patients with rheumatoid arthritis. Increased expression of CD97 in the synovium is accompanied by detectable levels of soluble CD97 in the synovial fluid.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	4 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0006928	cellular component movement
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007155	cell adhesion
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007267	cell-cell signaling
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000203 GPS motif
IPR000742 Epidermal growth factor-like domain
IPR000832 GPCR, family 2, secretin-like
IPR001740 GPCR, family 2, EMR1 hormone receptor
IPR001881 EGF-like calcium-binding domain
IPR003056 GPCR, family 2, CD97 antigen
IPR017981 GPCR, family 2-like

PFAM

PF01825
PF00008
PF00002
PF07645

PRINTS

PR00249
PR01128
PR01278

PIRSF

SMART

SM00303
SM00181
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt