InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TECR

Summary

InnateDB Protein

IDBP-33525.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TECR

Protein Name

trans-2,3-enoyl-CoA reductase

Synonyms

GPSN2; MRT14; SC2; TER;

Species

Homo sapiens

Ensembl Protein

ENSP00000215567

InnateDB Gene

IDBG-33523 (TECR)

Protein Structure

UniProt Annotation

Function

Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids. {ECO:0000269PubMed:12482854}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:12482854}; Multi-pass membrane protein {ECO:0000269PubMed:12482854}.

Disease Associations

Mental retardation, autosomal recessive 14 (MRT14) [MIM:614020]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269PubMed:21212097}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in most tissues tested. Highly expressed in skeletal muscle. {ECO:0000269PubMed:12482854}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors

Biological Process

GO:0006629	lipid metabolic process
GO:0019432	triglyceride biosynthetic process
GO:0030497	fatty acid elongation
GO:0035338	long-chain fatty-acyl-CoA biosynthetic process
GO:0042761	very long-chain fatty acid biosynthetic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0030176	integral component of endoplasmic reticulum membrane