Version 5.4
Homo sapiens Protein: PSMG1
Summary
InnateDB Protein IDBP-3370.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PSMG1
Protein Name proteasome (prosome, macropain) assembly chaperone 1
Synonyms C21LRP; DSCR2; LRPC21; PAC-1; PAC1;
Species Homo sapiens
Ensembl Protein ENSP00000370286
InnateDB Gene IDBG-3364 (PSMG1)
Protein Structure
UniProt Annotation
Function Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. {ECO:0000269PubMed:16251969, ECO:0000269PubMed:17707236}.
Subcellular Localization Cytoplasm. Endoplasmic reticulum.
Disease Associations
Tissue Specificity In the adult, detected in brain, colon, leukocytes, breast and testis. Widely expressed in the fetus. Also expressed in a variety of proliferating cell lines. {ECO:0000269PubMed:10872820, ECO:0000269PubMed:9784380}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 27 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0043248 proteasome assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95456
PhosphoSite PhosphoSite-O95456
TrEMBL
UniProt Splice Variant
Entrez Gene 8624
UniGene Hs.473838
RefSeq NP_982257
HUGO HGNC:3043
OMIM 605296
CCDS CCDS13661
HPRD 05598
IMGT
EMBL AB451468 AJ006291 AL163279 AY463963 BC003619 BC010424 BC011755 BC012809 BR000236 CH471079 CR541821 CR541852
GenPept AAH03619 AAH10424 AAH11755 AAH12809 AAR25628 BAG70282 CAA06957 CAB90451 CAG46620 CAG46650 EAX09664 EAX09665 FAA00022

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca