InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EMR2

Summary

InnateDB Protein

IDBP-33741.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EMR2

Protein Name

egf-like module containing, mucin-like, hormone receptor-like 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000319883

InnateDB Gene

IDBG-33739 (EMR2)

Protein Structure

UniProt Annotation

Function

Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. {ECO:0000269PubMed:12829604, ECO:0000269PubMed:17928360, ECO:0000269PubMed:22310662}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Cell projection, ruffle membrane; Multi-pass membrane protein. Note=Localized at the leading edge of migrating cells.

Disease Associations

Tissue Specificity

Expression is restricted to myeloid cells. Highest expression was found in peripheral blood leukocytes, followed by spleen and lymph nodes, with intermediate to low levels in thymus, bone marrow, fetal liver, placenta, and lung, and no expression in heart, brain, skeletal muscle, kidney, or pancreas. Expression is also detected in monocyte/macrophage and Jurkat cell lines but not in other cell lines tested. {ECO:0000269PubMed:10903844, ECO:0000269PubMed:11994511}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0035374	chondroitin sulfate binding

Biological Process

GO:0006954	inflammatory response
GO:0007155	cell adhesion
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0016477	cell migration
GO:0071621	granulocyte chemotaxis

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031256	leading edge membrane
GO:0032587	ruffle membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000203 GPS motif
IPR000742 Epidermal growth factor-like domain
IPR000832 GPCR, family 2, secretin-like
IPR001740 GPCR, family 2, EMR1 hormone receptor
IPR001881 EGF-like calcium-binding domain
IPR003056 GPCR, family 2, CD97 antigen
IPR017981 GPCR, family 2-like

PFAM

PF01825
PF00008
PF00002
PF07645

PRINTS

PR00249
PR01128
PR01278

PIRSF

SMART

SM00303
SM00181
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt