InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KATNB1

Summary

InnateDB Protein

IDBP-33758.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KATNB1

Protein Name

katanin p80 (WD repeat containing) subunit B 1

Synonyms

KAT;

Species

Homo sapiens

Ensembl Protein

ENSP00000368982

InnateDB Gene

IDBG-33756 (KATNB1)

Protein Structure

UniProt Annotation

Function

Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. {ECO:0000255HAMAP-Rule:MF_03022}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton. Note=Predominantly cytoplasmic. Localized to the interphase centrosome and mitotic spindle poles.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008568	microtubule-severing ATPase activity
GO:0045502	dynein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006605	protein targeting
GO:0007026	negative regulation of microtubule depolymerization
GO:0007079	mitotic chromosome movement towards spindle pole
GO:0010942	positive regulation of cell death
GO:0010976	positive regulation of neuron projection development
GO:0031117	positive regulation of microtubule depolymerization
GO:0051013	microtubule severing

Cellular Component

GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005874	microtubule
GO:0008352	katanin complex
GO:0016020	membrane
GO:0030424	axon
GO:0030426	growth cone
GO:0030496	midbody
GO:0043025	neuronal cell body