InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TAF2

Summary

InnateDB Protein

IDBP-33914.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAF2

Protein Name

TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa

Synonyms

CIF150; MRT40; TAF2B; TAFII150;

Species

Homo sapiens

Ensembl Protein

ENSP00000367406

InnateDB Gene

IDBG-33912 (TAF2)

Protein Structure

UniProt Annotation

Function

Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter. {ECO:0000269PubMed:9418870, ECO:0000269PubMed:9774672}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:9774672}.

Disease Associations

Mental retardation, autosomal recessive 40 (MRT40) [MIM:615599]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT40 affected individuals also show microcephaly, spasticity, thin corpus callosum, pyramidal signs. {ECO:0000269PubMed:24084144}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in all tissues tested. {ECO:0000269PubMed:9774672}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.

Experimentally validated
Total	28 [view]
Protein-Protein	25 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006508	proteolysis
GO:0014070	response to organic cyclic compound
GO:0045944	positive regulation of transcription from RNA polymerase II promoter